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Effect of folate on cervical cancer. Synergism among risk factors
1Department of Nutrition Sciences, University of Alabama, Birmingham 35294-3360.
Annals of the New York Academy of Sciences
|October 10, 1992
Abstract:
Folate deficiency appears to play a crucial role early in cervical carcinogenesis by facilitating the incorporation of HPV genomes at a fragile chromosomal site. Thereafter, multiple nutritional, hormonal, and immunologic factors probably interact in a synergistic manner to determine whether the cell line becomes immortalized and invasive.