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[Experimental studies of the inhibition of fibrogenesis]
K Böker1, G Schwarting, G Kaule
1Abteilung Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Frankfurt/M.
Zeitschrift Fur Gastroenterologie
|March 1, 1992
Abstract:
Colchicine as well HOE 077 were found to be effective in the inhibition of hepatic collagen accumulation after bile duct ligation in rats. The effect was additive and was truly reflected by changes in the serum PIIIP and 7s-collagen (IV) concentration. Extrahepatic effects on collagen synthesis were not detected when HOE 077 was used. Thus further studies on the potential clinical usefulness of these compounds are clearly indicated.