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Virus infection and hand papular dermatoses in young children
Abstract:
Four strains of enterovirus and 1 strain of adenovirus were isolated from stool and pharyngeal swabs by inoculation into primary human embryonic kidney cell culture in 25 cases of dorsum manus infantile papular dermatitis. Two strains of Coxsackie A-9 virus and 1 strain of Echovirus-25 were identified. With the isolated virus as antigen, a matched pair study by sera antibody test was carried out in 43 children with papular dermatitis and 40 normal individuals as controls. In 26 cases of Coxsackie A-9 virus positive papular dermatitis, a 4-fold rise (> 1:1.6) in the relative serum antibody was observed in 80.77%, while no high levels were observed in patients with Echovirus-25 and adenovirus dermatitis (< 1:16). The authors can reasonably conclude that epidemic Coxsackie A-9 virus infection is obviously related to infantile papular dermatitis and is probably the main cause of the disease.
Insights
Coxsackie A-9 virus is linked to infantile papular dermatitis. This study found a significant antibody rise in children with this skin condition, suggesting it
Area of Science:
- Virology
- Dermatology
- Pediatrics
Background:
- Infantile papular dermatitis is a skin condition affecting children.
- The etiology of infantile papular dermatitis is not fully understood.
- Viral infections are suspected causes of various pediatric dermatoses.
Purpose of the Study:
- To investigate the potential viral causes of infantile papular dermatitis.
- To determine the association between specific enteroviruses and papular dermatitis.
Main Methods:
- Viral isolation from stool and pharyngeal swabs of affected children using human embryonic kidney cell cultures.
- Serological testing (antibody levels) in children with papular dermatitis and healthy controls.
- Matched pair analysis comparing viral strains and antibody responses.
Main Results:
- Coxsackie A-9 virus and Echovirus-25 were isolated from cases of infantile papular dermatitis.
- A significant 4-fold rise in serum antibodies against Coxsackie A-9 virus was observed in 80.77% of affected children.
- No significant antibody rise was found for Echovirus-25 or adenovirus in dermatitis patients.
Conclusions:
- Epidemic Coxsackie A-9 virus infection is strongly associated with infantile papular dermatitis.
- Coxsackie A-9 virus is likely the primary causative agent of this infantile skin condition.
- Further research into viral etiologies of pediatric dermatological diseases is warranted.