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Captopril does not protect against renal oxidative injury
S A Chin1, J P Fawcett, R J Walker
1School of Pharmacy, University of Otago, Dunedin, New Zealand.
Abstract:
The free thiol group of captopril is important in the action and metabolism of this drug. It has been postulated that the thiol group may allow captopril to act in a manner similar to glutathione and protect against oxidative injury. This study investigated the ability of captopril, enalaprilat, and N-acetylcysteine to prevent tertbutyl hydroperoxide induced oxidative injury in rat renal homogenates. Lipid peroxidation was significantly increased in homogenates from captopril-treated animals (p < 0.05), and following glutathione depletion this was further enhanced (p < 0.001). Renal glutathione content was significantly reduced by captopril treatment (p < 0.01). These results suggest that captopril does not act as an alternate source of reducing equivalents to glutathione and does not protect against renal oxidative injury in this model.