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Histological grading of gliomas
1Service d'Anatomie Pathologique, Centre Hospitalier Sainte-Anne, Paris, France.
Current Opinion in Neurology and Neurosurgery
|December 1, 1992
Summary
Grading systems for gliomas using features like mitosis and necrosis are reliable only for some astrocytomas. Reproducibility issues hinder accurate prognosis for many glioma types, especially in children.
Area of Science:
- Neuro-oncology
- Pathology
- Cancer Grading Systems
Background:
- Current glioma grading systems rely on non-specific histological features.
- The reliability of these features varies significantly across different glioma subtypes.
Purpose of the Study:
- To evaluate the effectiveness of current grading systems for various glioma types.
- To identify limitations in glioma grading and prognosis.
Main Methods:
- Analysis of grading systems based on mitosis and necrosis.
- Assessment of reproducibility in conventional and kinetic methods.
Main Results:
- Grading is unequivocal only in certain astrocytomas.
- Efficacy in oligodendrogliomas, mixed oligo-astrocytomas, and ependymomas is uncertain.
- Reliable grading is limited to a small proportion of pediatric gliomas.
Conclusions:
- Non-specific features have limited utility for grading most gliomas.
- Lack of reproducibility is a major obstacle for glioma prognosis.
- Further research is needed to develop reliable grading methods for all gliomas.