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[Angina pectoris after sumatriptan (Imigran)].

B Abrahamsen1, B D Christiansen

  • 1Medicinsk afdeling, Varde Sygehus.

Ugeskrift for Laeger
|December 7, 1992
PubMed
Summary
This summary is machine-generated.

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Sumatriptan, a migraine treatment, may cause angina and ECG changes in patients with heart disease. This suggests a potential extracranial vasoconstrictor effect in this population.

Area of Science:

  • Cardiology
  • Pharmacology

Context:

  • Sumatriptan is a common migraine medication.
  • Subcutaneous sumatriptan typically does not cause significant ECG changes.
  • A case study is presented involving a 61-year-old male with a history of myocardial infarction.

Purpose:

  • To report a case of angina pectoris and significant ECG changes following sumatriptan administration.
  • To investigate the potential cardiovascular effects of sumatriptan in patients with ischemic heart disease.

Summary:

  • A 61-year-old male with a history of myocardial infarction experienced angina pectoris on two occasions after self-administering sumatriptan.
  • Both episodes of angina were associated with significant ST-segment depression on ECG monitoring.
  • The findings suggest a possible extracranial vasoconstrictor action of sumatriptan in patients with ischemic heart disease.

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Impact:

  • Highlights the potential cardiovascular risks of sumatriptan in patients with pre-existing ischemic heart disease.
  • Suggests the need for caution when prescribing sumatriptan to patients with cardiovascular conditions.
  • Warrants further investigation into the vasoconstrictive properties of sumatriptan in specific patient populations.