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Increase in plasma thrombomodulin and decrease in plasma von Willebrand factor after regular radiotherapy of patients
Thrombosis Research
|October 15, 1992
Summary
Plasma thrombomodulin (TM) increased with radiation dose in cancer patients undergoing radiotherapy, while von Willebrand factor (vWF) decreased. Elevated TM may indicate early radiation-induced endothelial cell injury.
Area of Science:
- Oncology
- Radiotherapy
- Biomarkers
Background:
- Radiotherapy can cause endothelial cell damage.
- Identifying early markers of radiation injury is crucial for patient management.
Purpose of the Study:
- To investigate plasma levels of thrombomodulin (TM) and von Willebrand factor (vWF) in cancer patients undergoing radiotherapy.
- To determine the correlation between these markers and radiation dose.
Main Methods:
- Studied 51 cancer patients undergoing cobalt radiotherapy.
- Measured plasma TM using immunoradiometric assay.
- Measured plasma vWF antigen using ELISA.
Main Results:
- Plasma TM levels increased during radiotherapy in a radiation-dose-dependent manner.
- Plasma vWF levels decreased during radiotherapy, inversely correlating with radiation dose.
- Observed a positive correlation between plasma TM and radiation doses.
Conclusions:
- Plasma TM is a potential early molecular marker for detecting radiation-induced endothelial cell injury.
- Changes in TM and vWF levels reflect endothelial cell response to radiotherapy.