Related Experiment Video
Updated: Aug 7, 2026

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
[Multifocal tuberculosis with cerebellar tuberculoma]
D Frappaz1, J Huppert, M H Deleage
1Unité de pédiatrie, hôpital Nord et hôpital Bellevue, St-Priest-en-Jarez, St-Etienne, France.
Insights
A 10-year-old child with disseminated tuberculosis presented with a cerebellar mass. Surgical removal and 18 months of treatment led to a full recovery and five-year follow-up.
Area of Science:
- Pediatrics
- Neurology
- Infectious Diseases
Background:
- Tuberculosis (TB) can present with rare neurological manifestations, even in immunized children.
- Disseminated tuberculosis involves multiple organ systems, posing diagnostic challenges.
Observation:
- A 10-year-old child presented with cerebellar syndrome, high fever, and vomiting.
- CT scans revealed an intracerebellar mass, splenic abscess, and mediastinal lymphadenopathy.
- Bone scintigraphy indicated multiple metastatic lesions.
Findings:
- Surgical exploration identified a cerebellar tuberculoma, which was completely resected.
- Histopathological confirmation of tuberculoma was obtained.
- The child completed 18 months of antituberculous therapy.
Implications:
- Early diagnosis and surgical intervention are crucial for managing cerebellar tuberculomas.
- Aggressive antituberculous treatment is effective in achieving long-term remission.
- This case highlights the importance of considering disseminated TB in pediatric neurological presentations.
Abstract:
A 10-year old child was admitted for vomiting and a high grade fever. He had been previously immunized twice against tuberculosis. A cerebellar syndrome appeared, and the brain CT scan showed an intracerebellar mass. Disseminated lesions were detected on abdominal (splenic abscess) and thoracic (mediastinal lymph nodes) CT scans. The bone scintigraphy also showed multiple localisations. A craniotomy was performed that revealed a cerebellar tuberculoma which was completely removed. The child received an antituberculous treatment over 18 months and is currently well with a 5 year follow-up.
Related Concept Videos
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Tuberculosis
Cryptococcal Meningitis

