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When should granulocyte function be checked?
1Department of Epidemiology, National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1992
Summary
Inherited granulocyte function abnormalities can cause severe infections and sepsis. Diagnosis involves neutrophil function tests like chemotaxis and the NBT test, prompting further investigation for treatment.
Area of Science:
- Immunology
- Hematology
- Clinical Medicine
Background:
- Granulocyte function abnormalities underlie recurrent severe infections, abscesses, delayed wound healing, and antibiotic-resistant sepsis.
- These dysfunctions can be inherited or acquired, with inherited forms detailed here.
- Neutrophil function failures should be considered in patients with conditions like diabetes, infections, and malignancies.
Purpose of the Study:
- To detail inherited granulocyte function abnormalities.
- To highlight the importance of considering neutrophil function in various clinical contexts.
- To outline diagnostic approaches for qualitative neutrophil function abnormalities.
Main Methods:
- Review of inherited neutrophil dysfunctions.
- Discussion of clinical presentations associated with granulocyte abnormalities.
- Description of diagnostic tools: chemotaxis, migration assays, and Nitroblue Tetrazolium (NBT) test.
Main Results:
- Inherited granulocyte defects are a significant cause of recurrent infections and sepsis.
- Neutrophil function testing, including chemotaxis and NBT, serves as an initial diagnostic step.
- Deviations in function tests necessitate further, more specific diagnostic determinations.
Conclusions:
- Inherited granulocyte dysfunction is a critical factor in severe, recurrent infections.
- Neutrophil function tests are essential for diagnosing these qualitative abnormalities.
- Early identification and further testing are crucial for managing patients with suspected granulocyte defects.