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Published on: February 6, 2017
[Gastroenteritis caused by adenoviruses 40/41: epidemiological and clinical aspects]
1Unidad de Microbiología, Hospital Nuestra Señora del Pino, Las Palmas de Gran Canaria.
Insights
Adenovirus 40/41 is a significant cause of pediatric gastroenteritis, particularly in children under two. This study highlights its role, peak infection times, and hospital-acquired infections.
Area of Science:
- Virology
- Pediatrics
- Epidemiology
Context:
- Gastroenteritis is a common illness in children.
- Adenovirus 40/41 is recognized as a significant pathogen.
- Understanding its prevalence and characteristics is crucial for public health.
Purpose:
- To evaluate the clinical and epidemiological significance of adenovirus 40/41 in pediatric gastroenteritis.
- To determine the incidence and patterns of adenovirus 40/41 infections in a specific pediatric population.
Summary:
- A 2-year prospective study analyzed 1,697 stool samples from children under 14 using enzyme immunoassay.
- Adenovirus 40/41 was identified as the third leading cause of gastroenteritis (2.1% infection rate), predominantly affecting children under 24 months.
- Peak infections occurred in September, with 46.2% of cases being hospital-acquired. Most cases presented as self-limited diarrhea, with good outcomes following rehydration.
Impact:
- Provides data on the prevalence and clinical impact of adenovirus 40/41 in pediatric gastroenteritis.
- Informs clinical management and public health strategies for controlling viral diarrheal diseases.
- Contributes to a better understanding of adenovirus 40/41 epidemiology, aiding in disease prevention and outbreak response.
Abstract:
The 40/41 adenovirus plays an important role as the productive agent of gastroenteritis at a pediatric age according to recent studies. With the aim of evaluating the clinical-epidemiological importance of this agent in our medium a prospective study of the 40/41 adenovirus was carried out in 1,697 stools of children of under 14 years of age over a period of 2 years. An enzyme immunoassay technique with specific monoclonal antibodies was used for detection. The 40/41 adenovirus was the third cause of gastroenteritis following Salmonella sp. and rotavirus with a percentage of infection of 2.1%. In 87.1% of the patients in which it was detected the patients had an age of less than 24 months. A clear peak of infection was found in the months of September of the two years studied. The infection was of intrahospital origin in 46.2% of the patients. Most of the children presented a self-limited diarrheic picture. The evolution of the patients was good with adequate rehydration measures. The study of the 40/41 adenovirus is of indubitable interest with the aim of obtaining greater knowledge of its importance in the epidemiology and clinical manifestations of gastroenteritis.
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