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Survey on spontaneous peripheral neuropathy in aging mice
1Huntingdon Research Centre Ltd., Pathology Department, Cambridgeshire, England.
Arzneimittel-Forschung
|November 1, 1992
Summary
Peripheral neuropathy incidence in CD-1 mice increases with age, affecting females more than males. This spontaneous condition was less common in CD-1 mice compared to B6C3F1 strains.
Area of Science:
- Veterinary Neurology
- Toxicology
- Animal Models
Background:
- Peripheral neuropathy is a significant concern in long-term rodent studies.
- Understanding incidence rates and risk factors is crucial for data interpretation.
Purpose of the Study:
- To report the incidence of spontaneous peripheral neuropathy in CD-1 mice.
- To analyze age- and sex-related differences in neuropathy occurrence.
- To compare neuropathy incidence between CD-1 and B6C3F1 mouse strains.
Main Methods:
- A retrospective analysis of peripheral nerve samples from 15,223 male and 15,075 female CD-1 mice over a 10-year period.
- Inclusion of mice aged 80 to 104 weeks in the incidence calculation.
- Comparison of neuropathy rates between CD-1 and B6C3F1 strains.
Main Results:
- The overall incidence of peripheral neuropathy was 8% in males and 12% in females (aged 80-104 weeks).
- Neuropathy incidence demonstrated a clear age-related trend.
- Females exhibited a higher incidence than males, and CD-1 mice showed lower rates than B6C3F1 mice.
Conclusions:
- Spontaneous peripheral neuropathy in CD-1 mice is age- and sex-dependent.
- The CD-1 strain presents a lower incidence of peripheral neuropathy compared to the B6C3F1 strain.
- These findings are important for interpreting toxicological and long-term study data in rodents.