Survey on spontaneous peripheral neuropathy in aging mice

The incidence of peripheral neuropathy in CD-1 mice (caesarean-derived) obtained from long term studies over a 10 year period is reported. The survey included peripheral nerve samples of 15,223 males and 15,075 females. The incidence of peripheral neuropathy is 8% in untreated males and 12% in untreated females aged 80 to 104 weeks. The total incidence in all mice in the survey was higher in females than males and was age-related. The present survey also showed interstrain differences. The peripheral neuropathy in CD-1 strain was low in incidence compared to B6C3F1 (cross between C57 BL/C6NCLB and C3H/HENCRLB). The peripheral neuropathy was spontaneous in origin and was age-related.