[A nontraditional approach to anesthesiological support and intensive therapy in neurosurgery]

Using mediator agents in definite combinations allows one to simulate the functions of the genetically determined levels of adaptive reaction integration. The action of combinations of narcotic analgetics with varying receptor affinity and alpha 2-adrenomimetics impoverishes and modulates a flow of sensory information to the higher centers of autonomic integration and largely relieves efferent impulsation. This ensures harmonicity of the reactions and makes for the operation of local sanogenetic mechanisms of the brain at functional rest. Anesthesia performed in the early postoperative period by using a combination of the narcotic analgetic phentanyl and the centrally acting alpha 2-adrenoagonist clofelin enables the authors to significantly improve the outcomes of treatment.