[N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE AS BIOMARKER OF ACUTE BRAIN INJURY]

Laboratory diagnostic is very important in treatment of acute brain injury, together with neurophysiology and neurovisualisation methods. Biomarkers measurements can provide early brain injury diagnostic, monitoring of treatment as well as outcome prediction. We studied dynamic of N-terminal pro-brain natriuretic peptide (n-proBNP) level in patients with acute brain injury (intracranial hemorrage, traumatic brain injury, tumors). All patients were divided into 3 groups (by etiology of injury), each group consist of 2 subgroups: a - survivors with good outcome (I-II group in Glasgow outcome scale (GOS)); b - dead or severe morbidity (III-V group in GOS). High level of n-proBNP was mentioned in all groups. N-proBNP level was not correlated with etiology of injury. In cases of n-proBNB increasing more than 700pg/ml outcome was poor - severe morbidity or death. We suppose N-proBNP can be significant acute brain injury biomarker, useful to outcome prediction.