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HLA antibodies in multiple transfused patients
1Department of Laboratory Medicine, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed
|December 1, 1992
Summary
About one-third of patients receiving multiple blood transfusions develop Human Leukocyte Antigen (HLA) antibodies. Antibody reactivity correlates with the volume of blood components transfused, highlighting transfusion risks.
Area of Science:
- Immunology
- Transfusion Medicine
- Clinical Pathology
Background:
- Multiple blood transfusions are essential for managing various medical conditions.
- Patients undergoing frequent transfusions face risks, including alloimmunization.
- Human Leukocyte Antigen (HLA) antibodies can complicate future transfusions and transplants.
Purpose of the Study:
- To investigate the incidence of Human Leukocyte Antigen (HLA) antibody development in patients receiving multiple transfusions.
- To identify specificities of developed HLA antibodies.
- To explore the correlation between the volume of transfused blood components and HLA antibody reactivity.
Main Methods:
- Prospective follow-up of 86 patients with multiple transfusions for over six months.
- Regular serum screening for HLA antibodies every two to four weeks.
- Analysis of antibody specificities and correlation of panel reactive activity (PRA) with transfusion volume.
Main Results:
- 28 out of 86 patients (33%) developed HLA antibodies.
- Identified antibody specificities included anti-A2, A11, B16, and B60, with many being multiple or undetermined.
- A correlation was observed between panel reactive activity (PRA) and the amount of blood components transfused.
Conclusions:
- Approximately one-third of patients develop HLA antibodies following multiple transfusions.
- The level of HLA antibody reactivity is associated with the quantity of blood components transfused.
- These findings underscore the importance of monitoring for HLA antibodies in regularly transfused patients.