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The effect of nizatidine on neuromuscular transmission
1Department of Pharmacology, Chemotherapy and Toxicology Emilio Trabucchi, University of Milan, Italy.
In Vivo (Athens, Greece)
|November 1, 1992
Abstract:
The effect of the H2-receptor antagonist, nizatidine, on neuromuscular transmission was investigated using sciatic nerve-gastrocnemius muscle preparations of rat in vivo. Nizatidine, administered by i.v. injection, potentiates the neuromuscular blockade induced by d-tubocurarine, pancuronium and the aminoglycoside antibiotic, kanamycin. Moreover, the drug alone is capable of producing a blockade on preparations stimulated at high frequency. The neuromuscular blockade induced by nizatidine is reversed by 4-aminopyridine but not by dimaprit.