Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retinoid receptors and binding proteins.

D Lohnes1, A Dierich, N Ghyselinck

  • 1Laboratoire de Génétique Moléculaire, Eucaryotes du CNRS, Strasbourg, France.

Journal of Cell Science. Supplement
|January 1, 1992
PubMed
Summary

Retinoids, like all-trans retinoic acid (T-RA), are vital for vertebrate development. This study investigates the molecular mechanisms of retinoid signaling by genetically modifying retinoic acid receptors (RARs) and binding proteins in mice.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A system for detecting high impact-low frequency mutations in primary tumors and metastases.

Oncogene·2017
Same author

Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.

Cell death & disease·2016
Same author

Changes in muscle activation during gait of children with duchenne muscular dystrophy.

Computer methods in biomechanics and biomedical engineering·2015
Same author

NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT.

Cell death & disease·2015
Same author

Prognostic factors for the recurrence of myxoid liposarcoma: 20 cases with up to 8 years follow-up.

Orthopaedics & traumatology, surgery & research : OTSR·2015
Same author

Transgenic mice: 'new wave' immunogenetics.

Immunology today·2014

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Biochemistry

Background:

  • Retinoids, including all-trans retinoic acid (T-RA), are crucial for vertebrate development and homeostasis.
  • While retinoid effects like teratogenicity are known, their underlying molecular mechanisms are still being uncovered.
  • The retinoid signaling pathway involves multiple binding proteins and receptors, with complex interactions determining cellular responses.

Purpose of the Study:

  • To elucidate the molecular mechanisms of retinoid signaling.
  • To understand the specific roles of different components within the retinoid pathway.
  • To investigate retinoid function in vivo using genetically modified models.

Main Methods:

  • Gene targeting of retinoic acid receptors (RARs).

Related Experiment Videos

  • Functional inactivation of cellular retinoid-binding proteins.
  • Generation of genetically modified mice to study retinoid signaling pathways.

    • Main Results:

    • Successfully generated mice with inactivated RARs and/or retinoid-binding proteins.
    • Established a model system for dissecting retinoid signaling mechanisms in vivo.
    • Provided a foundation for further research into the specific functions of each pathway component.

    Conclusions:

    • Understanding retinoid signaling is essential for comprehending development and homeostasis.
    • Genetically modified mouse models are powerful tools for dissecting complex signaling pathways.
    • Further research is needed to fully characterize the roles of individual retinoid pathway components.