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Angioedema complicating lisinopril therapy
1Department of Internal Medicine, Texas Technical University Medical Centre, Indiana Lubbock 79430.
The Central African Journal of Medicine
|September 1, 1992
Summary
Lisinopril, an antihypertensive medication, can cause angioedema, a serious swelling condition. Prompt treatment with antihistamines and steroids can effectively resolve symptoms.
Area of Science:
- Pharmacology
- Clinical Medicine
- Toxicology
Background:
- Hypertension is a prevalent condition often managed with angiotensin-converting enzyme (ACE) inhibitors.
- Lisinopril is a commonly prescribed ACE inhibitor for hypertension.
- Drug-induced angioedema is a known but potentially severe adverse reaction to ACE inhibitors.
Observation:
- A 70-year-old Black female with a 15-year history of hypertension developed acute oro-facial swelling and respiratory distress.
- Symptoms began after a three-day course of lisinopril.
- Clinical diagnosis of drug-induced angioedema was established.
Findings:
- The patient's angioedema and respiratory distress resolved within 24 hours following intravenous diphenhydramine and hydrocortisone.
- This case highlights lisinopril as a potential trigger for angioedema.
Implications:
- Angioedema is a critical, potentially life-threatening complication of lisinopril and other ACE inhibitors.
- Early recognition and treatment with antihistamines and corticosteroids are crucial for managing ACE inhibitor-induced angioedema.
- Clinicians should maintain a high index of suspicion for angioedema in patients on ACE inhibitors presenting with relevant symptoms.