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Angioedema complicating lisinopril therapy.

¹Department of Internal Medicine, Texas Technical University Medical Centre, Indiana Lubbock 79430.

The Central African Journal of Medicine

|September 1, 1992

Summary

Lisinopril, an antihypertensive medication, can cause angioedema, a serious swelling condition. Prompt treatment with antihistamines and steroids can effectively resolve symptoms.

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Area of Science:

Pharmacology
Clinical Medicine
Toxicology

Background:

Hypertension is a prevalent condition often managed with angiotensin-converting enzyme (ACE) inhibitors.
Lisinopril is a commonly prescribed ACE inhibitor for hypertension.
Drug-induced angioedema is a known but potentially severe adverse reaction to ACE inhibitors.

Observation:

A 70-year-old Black female with a 15-year history of hypertension developed acute oro-facial swelling and respiratory distress.
Symptoms began after a three-day course of lisinopril.
Clinical diagnosis of drug-induced angioedema was established.

Findings:

The patient's angioedema and respiratory distress resolved within 24 hours following intravenous diphenhydramine and hydrocortisone.
This case highlights lisinopril as a potential trigger for angioedema.

Implications:

Angioedema is a critical, potentially life-threatening complication of lisinopril and other ACE inhibitors.
Early recognition and treatment with antihistamines and corticosteroids are crucial for managing ACE inhibitor-induced angioedema.
Clinicians should maintain a high index of suspicion for angioedema in patients on ACE inhibitors presenting with relevant symptoms.

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