Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Ewing's tumor: current knowledge and ignorance].

J C Gentet1, M Panuel, C Sheiner

  • 1Service d'oncologie, hôpitaux de La Timone, Marseille, France.

Pediatrie
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic parameters of slaughter traits measured on Greylag geese after induction of spontaneous liver steatosis.

Animal : an international journal of animal bioscience·2025
Same author

Long-term morbidity and mortality in 2-year hepatoblastoma survivors treated with SIOPEL risk-adapted strategies.

Hepatology international·2021
Same author

Analysis of diagnosis announcements in Abidjan pediatric oncology unit 2 years after introduction of the African Pediatric Cancer Announcement Guideline.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2019
Same author

Expanding the Distinctive Neuroimaging Phenotype of <i>ACTA2</i> Mutations.

AJNR. American journal of neuroradiology·2018
Same author

Magnetic resonance spectroscopy in very preterm-born children at 4 years of age: developmental course from birth and outcomes.

Neuroradiology·2018
Same author

Vancomycin in Pediatric Patients with Solid or Hematological Malignant Disease: Predictive Performance of a Population Pharmacokinetic Model and New Optimized Dosing Regimens.

Paediatric drugs·2018
Same journal

[Colonic atresia: report of a case].

Pediatrie·1993
Same journal

[Psychological aspects of bone marrow donation in donor brothers and sisters in bone marrow transplantation].

Pediatrie·1993
Same journal

[Lethargy in the course of treatment with ranitidine in a newborn infant].

Pediatrie·1993
Same journal

[Delayed detection of hip dislocation: is the physician to blame?].

Pediatrie·1993
Same journal

[Renal tubular acidosis in children].

Pediatrie·1993
Same journal

[CD23: structures, functions and practical perspectives in allergy reactions].

Pediatrie·1993
See all related articles

Diagnosing Ewing's sarcoma in young patients is challenging due to its rarity and varied symptoms, often leading to misdiagnosis. Advanced diagnostic methods and multidisciplinary treatment strategies improve disease-free survival rates to 60-70%.

Area of Science:

  • Pediatric Oncology
  • Skeletal Tumors
  • Diagnostic Imaging

Background:

  • Ewing's sarcoma presents diagnostic challenges in young patients due to rarity, diverse symptoms, and imaging pitfalls.
  • Misdiagnosis as osteomyelitis is common, highlighting the need for accurate diagnostic methods.

Purpose of the Study:

  • To outline the diagnostic and therapeutic challenges of Ewing's sarcoma in pediatric patients.
  • To review current management strategies and survival outcomes.

Main Methods:

  • Histological diagnosis via biopsy of undifferentiated small round cell tumors.
  • Cytogenetic analysis for the specific (11;22)(q24;q12) translocation.
  • Immunocytochemistry and molecular biology to confirm neuroectodermal origin.

Related Experiment Videos

Main Results:

  • Chemotherapy followed by surgical resection and orthopedic reconstruction is a primary treatment approach.
  • Radiotherapy use is decreasing, reserved for specific cases due to long-term sequelae.
  • Intensified chemotherapy is considered for high-risk factors like poor response, large tumor size, or metastasis.

Conclusions:

  • Current therapeutic strategies have improved disease-free survival rates to 60-70%.
  • Management requires a multidisciplinary approach and inclusion in multicentric therapeutic trials.
  • Long-term follow-up is crucial for patients treated for Ewing's sarcoma.