Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antisense RNA. History and perspective.

S Pestka1

  • 1Department of Molecular Genetics and Microbiology, UMDNJ-Robert Wood Johnson Medical School, Piscataway 08854-5635.

Annals of the New York Academy of Sciences
|October 28, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patents and literature.

Applied biochemistry and biotechnology·2013
Same author

Up-regulation of a tumor-associated antigen (tag-72) by interferon-alpha and interferon-gamma in patients with cutaneous breast-cancer recurrences.

International journal of oncology·2011
Same author

Injection of irradiated b16 melanoma genetically-modified to secrete IFN-alpha causes regression of an established tumor.

International journal of oncology·2011
Same author

IFN-gamma and b7 as costimulators of antitumor immune-responses.

International journal of oncology·2011
Same author

Purification and cloning of interferon alpha.

Current topics in microbiology and immunology·2007
Same author

Differential IL-10R1 expression plays a critical role in IL-10-mediated immune regulation.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

Antisense RNA, a molecule that inhibits protein synthesis, was initially an in vitro finding. Researchers are developing strategies to effectively use artificial antisense RNA in cells by finding targets and amplifying RNA levels.

Area of Science:

  • Molecular Biology
  • Gene Regulation
  • RNA Therapeutics

Background:

  • Antisense RNA was initially observed to inhibit protein synthesis in cell-free systems.
  • Natural antisense RNA regulates protein synthesis in prokaryotic organisms.
  • Artificial antisense constructs offer potential for gene silencing in various cell types.

Observation:

  • Antisense RNA can effectively inhibit protein synthesis in both prokaryotic and eukaryotic cells.
  • High concentrations of antisense RNA relative to sense RNA are necessary for effective inhibition.
  • Identifying suitable gene targets and amplifying antisense RNA are key challenges.

Findings:

  • This report summarizes original research on the application and challenges of antisense RNA technology.

Related Experiment Videos

  • Strategies for target identification and RNA amplification are crucial for effective antisense RNA function.
  • The study highlights the potential of artificial antisense constructs for modulating protein synthesis.

    • Implications:

    • Advances in antisense RNA technology could lead to novel therapeutic strategies for diseases caused by protein overexpression.
    • Understanding antisense RNA mechanisms is vital for developing targeted gene regulation approaches.
    • Further research into antisense RNA amplification and delivery is needed for clinical translation.