Entamoeba histolytica: phylogenetic considerations. A review

Comparison of 16S rRNA sequences alone positions E. histolytica in rRNA-based phylogenies branching after flagellates such as Euglenoids and Kinetoplastids, whereas morphological and functional features had suggested an earlier branching and different relationships. As several characteristics of this parasite do not precisely adjust to the phylogenetic frame obtained by comparison of ribosomal sequences, and the inferences from this approach could be skewed because of the high A+T content of Entamoeba rDNA, a re-evaluation of E. histolytica phylogeny seems convenient at this point. The data about genomic and protein sequences could provide bases to complement or expand the rRNA-based phylogeny.