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Endocrine abortion in assisted reproduction technologies (ART)
F Coppola1, G Tridenti, C Barletta
1Dept. of Obstetric and Gynaecology, University of Parma, Italy.
Acta Bio-Medica De L'Ateneo Parmense : Organo Della Societa Di Medicina E Scienze Naturali Di Parma
|January 1, 1992
Summary
Assisted reproductive technology (ART) success is linked to luteo-endometrial function and embryo quality. Improving endometrial receptivity through progesterone or specific techniques may reduce ART
Area of Science:
- Reproductive Endocrinology
- Embryology
- Infertility Treatment
Background:
- Embryo implantation is controlled by luteal function, endometrial receptivity, and embryo quality.
- Endometrial factors influencing implantation are progesterone-dependent.
- Assisted reproductive technology (ART) has a significant abortion rate, potentially linked to poor luteo-endometrial function and embryo quality.
Purpose of the Study:
- To investigate factors affecting embryo implantation and ART success rates.
- To explore strategies for improving endometrial receptivity and reducing ART-associated abortions.
- To assess the predictive value of hormonal and endometrial markers on early pregnancy outcomes.
Main Methods:
- Analysis of 128 ART cycles (AIH-IU, GIFT, IVF-ET) performed between 1986-1991.
- Evaluation of luteal function, endometrial receptivity, and embryo quality.
- Preliminary assessment of beta-hCG, estradiol levels, and endometrial thickness for predicting pregnancy outcome.
Main Results:
- A pregnancy rate of 24.21% and an abortion rate of 22.58% were observed in the studied ART cycles.
- Controlled ovarian hyperstimulation may decrease endometrial receptivity, potentially increasing implantation failure.
- Exogenous progesterone administration and tubal techniques (GIFT, TET) showed potential to improve endometrial receptivity.
Conclusions:
- Poor luteo-endometrial function and embryo quality may contribute to high ART abortion rates.
- Strategies to enhance endometrial receptivity, such as progesterone support or specific ART techniques, are crucial for improving ART outcomes.
- Delayed embryo transfer to the blastocyst stage and monitoring hormonal/endometrial factors may enhance implantation rates and predict pregnancy success.