[Therapeutic plasmapheresis in suppurative-septic surgery]

Area of Science:

• Surgical Infections
• Critical Care Medicine
• Blood Purification Techniques

Background:

• Acute purulent surgical infections present significant clinical challenges.
• Endotoxemia is a critical factor in the progression of these infections.
• Plasmapheresis is a potential therapeutic intervention for severe infections.

Purpose of the Study:

• To evaluate the clinical efficacy of therapeutic plasmapheresis in patients with acute purulent surgical infections.
• To assess the impact of plasmapheresis on endotoxemia markers.
• To define optimal indications, contraindications, and procedural improvements for plasmapheresis in critical care.

Main Methods:

• Clinico-laboratory analysis of 69 patients undergoing therapeutic plasmapheresis.
• Monitoring of clinical disease progression.
• Assessment of endotoxemia markers pre- and post-perfusion.

Main Results:

• Significant improvement in the clinical picture of acute purulent surgical infections observed.
• Attenuation of endotoxemia noted by day 3 post-plasmapheresis.
• Analysis of factors contributing to procedure success and failure.

Conclusions:

• Therapeutic plasmapheresis is an effective treatment modality for acute purulent surgical infections.
• Early plasmapheresis can mitigate endotoxicosis and improve patient outcomes.
• Refined protocols can enhance the success rate of plasmapheresis in critical patients.