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Related Experiment Videos

[Toxocariasis in children].

N Prazić1, D Richter

  • 1Medicinskog fakulteta, Klinika za djecje bolesti, Salata, Zagreb.

Lijecnicki Vjesnik
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

Toxocariasis in children often presents with high eosinophilia. While thiabendazole treatment reduces eosinophil counts, levels often rise again, indicating the need for considering toxocariasis in diagnosing high eosinophil cases.

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Area of Science:

  • Pediatric Infectious Diseases
  • Clinical Immunology
  • Parasitology

Context:

  • Presents a series of ten pediatric cases of toxocariasis.
  • Patients exhibited high eosinophilia with non-specific health disturbances.
  • Geophagia was noted in three of the children.

Purpose:

  • To describe the clinical presentation and diagnostic findings of toxocariasis in children.
  • To evaluate the efficacy of thiabendazole treatment for toxocariasis.
  • To emphasize the importance of considering toxocariasis in the differential diagnosis of pediatric hypereosinophilia.

Summary:

  • Ten children (6 girls, 4 boys; aged 21 months to 9 years) with toxocariasis were identified via enzyme-linked immunosorbent assay (ELISA) due to significant eosinophilia (median 6007/mm³).

Related Experiment Videos

  • Treatment with thiabendazole (30-50 mg/kg BID for 5 days) resulted in an initial decrease in eosinophil counts (median 837/mm³).
  • However, eosinophilia recurred within 2-8 weeks, albeit at lower levels, highlighting potential challenges in sustained treatment response.

    • Impact:

    • Suggests toxocariasis should be a key consideration in the differential diagnosis of pediatric high peripheral eosinophilia.
    • Highlights that while patients are often in good general health, severe cases may require aggressive treatment.
    • Provides insights into the treatment response and potential relapse patterns of toxocariasis in children.