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Updated: Sep 15, 2026

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
06:03

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

Published on: July 15, 2019

Neuropathogenicity of group A Coxsackie viruses

G DALLDORF

    The Journal of Experimental Medicine
    |July 1, 1957
    PubMed

    Insights

    Coxsackie virus A14 adapted to adult mice and monkeys causes poliomyelitis-like symptoms. Infected mice developed flaccid paralysis, indicating significant neurological impact.

    Area of Science:

    • Virology
    • Neurology
    • Pathology

    Background:

    • Coxsackie viruses are known human enteroviruses.
    • Previous research has focused on other strains' neurotropic potential.

    Purpose of the Study:

    • To investigate the pathogenicity of Coxsackie virus, Group A, Type 14 (CAV-14) in adult animal models.
    • To determine if CAV-14 can induce neurological disease similar to poliomyelitis.

    Main Methods:

    • Adaptation of CAV-14 to adult mice and monkeys.
    • Observation and documentation of clinical signs and pathological lesions.

    Main Results:

    • CAV-14 successfully adapted to both adult mice and monkeys.
    • Both species exhibited poliomyelitis-like lesions.
    • Adult mice specifically developed flaccid paralysis.

    Conclusions:

    • CAV-14 demonstrates neurovirulence in adult mice and monkeys.
    • The virus can induce paralytic disease, highlighting its potential as a model for poliomyelitis research.
    Keywords:
    COXSACKIE VIRUSES/infectionsMYOSITIS/experimentalPOLIOMYELITIS/experimental

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