Testicular proteins and DNA in experimental fluorosis

Experimental fluorosis was induced in young male albino rabbits by exposing them to 0, 5, 10, 20 and 50 mg of NaF via subcutaneous injections for a period of 3-1/2 months. The testicular structural, nuclear and total proteins were significantly depleted in all test groups of animals as compared to the control. There was a significant (p < 0.001) reduction in the testicular DNA after drug administration. The relevance of these results in experimental fluorosis has been discussed.