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Behavioral effects of neural transplantation
D F Emerich1, M Ragozzino, M N Lehman
1Cyto Therapeutics, Inc., Providence, RI 02906.
Cell Transplantation
|January 1, 1992
Summary
Neural tissue transplantation shows promise for central nervous system (CNS) disorders but can yield varied behavioral outcomes. This review explores both beneficial and detrimental effects of neural transplants in animal models.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Behavioral Science
Background:
- Fetal neural tissue transplantation is investigated for treating central nervous system (CNS) disorders.
- Transplants may ameliorate behavioral deficits in animal models, but outcomes are inconsistent.
Purpose of the Study:
- To review the beneficial and deleterious behavioral consequences of neural transplants in animal models of human diseases.
- To discuss potential mechanisms underlying transplant-induced behavioral recovery or deficits.
Main Methods:
- Review of existing literature on neural transplantation in animal models.
- Analysis of studies reporting behavioral outcomes following transplantation.
Main Results:
- Neural transplants can reduce or eliminate behavioral deficits in various CNS disorder models.
- However, transplants may also fail to improve behavior, worsen existing abnormalities, or cause new deficits.
Conclusions:
- Neural transplantation holds therapeutic potential for neurodegenerative disorders like Parkinson's disease.
- Understanding the mechanisms of both positive and negative behavioral effects is crucial for clinical translation.