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Automation and other recent developments in clinical chemistry
1Department of Pathology/Laboratory Medicine, Medical University of South Carolina, Charleston 29425.
American Journal of Clinical Pathology
|October 1, 1992
Summary
The 1980s revolutionized clinical chemistry with advanced automated analyzers and sensitive detection methods. Innovations in laboratory automation and computerization significantly improved efficiency and data integration.
Area of Science:
- Clinical Chemistry
- Laboratory Medicine
- Biotechnology
Background:
- The 1980s marked a period of significant advancement in clinical chemistry.
- Technological progress introduced new assay techniques and instrumentation.
- The field experienced rapid, albeit turbulent, growth.
Purpose of the Study:
- To review the progressive developments in clinical chemistry during the 1980s.
- To highlight key technological innovations and their impact.
- To discuss the maturation of laboratory automation and computerization.
Main Methods:
- Review of advancements in multichannel analyzers and spectrophotometry.
- Examination of the application of antigen-monoclonal antibody reactions for sensitive detection.
- Analysis of emerging technologies for serum processing and specimen handling.
- Assessment of laboratory computerization, including expert systems and robotics.
Main Results:
- Multichannel analyzers achieved near-perfection in automated laboratory functions.
- Highly sensitive detection methods, reaching the picomole/liter range, became routine.
- Automation of serum processing and specimen distribution saw emerging devices.
- Laboratory computerization matured, enhancing instrument integration and communication.
Conclusions:
- The 1980s laid a foundation for modern automated and computerized clinical laboratories.
- Innovations significantly enhanced the sensitivity and efficiency of chemical assays.
- The integration of technology, including expert systems and robotics, transformed laboratory practices.