Related Experiment Video

Updated: Aug 8, 2026

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
10:18

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

Strong expression of Fc-receptors on leukemic cells in hairy cell leukemia

E P Rieber, J G Saal, G Riethmüller

    Zeitschrift Fur Immunitatsforschung, Experimentelle Und Klinische Immunologie
    |April 1, 1976
    PubMed

    The neoplastic cells of a patient with hairy cell leukemia were found to express a high Fc-receptor actitivy on their surface. When the Fc-receptors were determined quantitatively by measuring the uptake of 125I-labelled aggregated IgG under saturation conditions, it was found that the hariy cells bound approximately 3 times more aggregated IgG than normal adherent mononuclear cells. The bound 125I-Agg. IgG was evenly distributed on the cell surface when the cells were labelled at 4 degrees C and was rapidly redistributed in form of a cap at one cell pole during incubation at 20 degrees C.

    More Related Videos

    Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells10:21

    Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

    Published on: February 21, 2018

    Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish08:32

    Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

    Published on: February 22, 2019

    Related Concept Videos

    Differentiation of Common Myeloid Progenitor Cells01:15

    Differentiation of Common Myeloid Progenitor Cells

    Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
    Regulation of Hematopoietic Stem Cells01:01

    Regulation of Hematopoietic Stem Cells

    All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...