Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Portal hypertension.

F M Karrer1

  • 1Department of Surgery, Children's Hospital, Denver, CO.

Seminars in Pediatric Surgery
|May 1, 1992
PubMed
Summary
This summary is machine-generated.

Portal hypertension in children, often caused by extrahepatic obstruction, leads to serious complications like variceal hemorrhage. Treatment has shifted from shunts to endoscopic therapies and liver transplantation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extraperitoneal placement of renal allografts in children weighing less than 15 kg.

The Journal of urology·2001
Same author

Survival after first esophageal variceal hemorrhage in patients with biliary atresia.

The Journal of pediatrics·2001
Same author

Life-threatening dog attacks: a devastating combination of penetrating and blunt injuries.

Journal of pediatric surgery·2001
Same author

Neonatal cholestasis.

Seminars in pediatric surgery·2000
Same author

Hepatoblastoma in a neonate: a hypervascular presentation mimicking hemangioendothelioma.

Pediatric radiology·2000
Same author

Cervical spine trauma in the injured child: a tragic injury with potential for salvageable functional outcome,.

Journal of pediatric surgery·2000
Same journal

The EXTra-uterine Environment for Neonatal Development (EXTEND) - future treatment for prematurity and potentially other congenital disease.

Seminars in pediatric surgery·2026
Same journal

Appendicitis as a model for pediatric surgical quality improvement and standardization.

Seminars in pediatric surgery·2026
Same journal

From FOB to PICU: military trauma systems that changed pediatrics.

Seminars in pediatric surgery·2026
Same journal

Long-term follow-up after surgery for congenital anomalies: A time to complication analysis.

Seminars in pediatric surgery·2026
Same journal

Radio-surgical decision-making in hepatoblastoma in the post-PHITT era: SIOPEL consensus recommendations.

Seminars in pediatric surgery·2026
Same journal

Seminars in pediatric sugery pediatric metabolic and bariatric surgery.

Seminars in pediatric surgery·2026
See all related articles

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Vascular Biology

Background:

  • Portal hypertension results from increased resistance to splanchnic flow and increased portal blood flow.
  • Key clinical outcomes include esophageal variceal hemorrhage, ascites, and hypersplenism.
  • Etiologies differ significantly between pediatric and adult populations.

Purpose of the Study:

  • To review the causes, clinical manifestations, and evolving treatment strategies for pediatric portal hypertension.
  • To highlight the shift in etiology from extrahepatic to intrahepatic causes in children.
  • To discuss the transition in therapeutic approaches.

Main Methods:

  • Literature review focusing on pediatric portal hypertension.
  • Analysis of etiological factors and treatment modalities.

Related Experiment Videos

  • Comparison of pediatric and adult causes and treatments.

    • Main Results:

    • Extrahepatic obstruction, particularly portal vein thrombosis, is the most common cause in children.
    • Intrahepatic obstruction is increasing due to improved survival in conditions like biliary atresia and cystic fibrosis.
    • Portosystemic shunt procedures are largely replaced by endoscopic treatments and liver transplantation.

    Conclusions:

    • Pediatric portal hypertension requires distinct diagnostic and management approaches compared to adults.
    • The increasing incidence of intrahepatic causes necessitates ongoing research into effective treatments.
    • Modern management emphasizes endoscopic interventions and liver transplantation for severe cases.