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Related Experiment Videos

[Hemorheologic changes in diabetes mellitus].

V Koblar1, I Kulenović, M Grujić

  • 1Zavod za transfuziologiju, Klinicki centar Sarajevo.

Medicinski Arhiv
|January 1, 1992
PubMed
Summary

Diabetic patients exhibit abnormal blood viscosity, impacting erythrocyte function. Managing metabolic control is key to improving blood flow and preventing diabetic complications.

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Area of Science:

  • Hematology
  • Endocrinology
  • Vascular Biology

Context:

  • Diabetes mellitus is a metabolic disorder associated with microvascular complications.
  • Haemorheological parameters, including blood viscosity and erythrocyte properties, are crucial for microcirculation.
  • Altered haemorheology is increasingly recognized as a contributing factor to diabetic complications.

Purpose:

  • To investigate the haemorheological profile of diabetic patients.
  • To compare haemorheological changes between different types of diabetes (IDDM and NIDDM).
  • To assess the influence of metabolic control and microangiopathy on haemorheological parameters in diabetes.

Summary:

  • This study evaluated 78 diabetic patients and 100 healthy controls, assessing whole blood viscosity, plasma viscosity, erythrocyte aggregability, and rigidity.
  • Diabetics showed hyperviscosity compared to controls. IDDM patients had more pronounced erythrocyte rigidity changes, while NIDDM patients exhibited greater cell aggregability alterations.
  • These haemorheological changes were present even before clinical onset of late diabetic complications and were exacerbated by poor metabolic control and existing complications.

Impact:

  • Metabolic derangements in diabetes significantly influence haemorheological properties.
  • Reducing blood viscosity in diabetics may improve microcirculation.
  • Targeting haemorheological parameters could be a promising strategy to delay the progression of diabetic microangiopathy.

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