[Diarrhea in immunopathies].

Area of Science:

• Gastroenterology
• Immunology
• Pathophysiology

Context:

• Immunologic gut diseases manifest with diarrhea, regardless of sensitization type (hetero- or auto-) or disease scope (local or generalized).
• The immunopathogenetic mechanism is intrinsically linked to antigen presence and its persistence.
• Antigen persistence dictates symptom manifestation and duration.

Purpose:

• To elucidate the role of antigens in the manifestation and resolution of diarrhea in immunologic gut diseases.
• To differentiate therapeutic approaches based on the type of immunologic gut disease.

Summary:

• Diarrhea is the hallmark symptom across various immunologic gut conditions.
• The resolution of diarrhea is contingent upon the elimination of the causative antigen.
• Autosensitization necessitates pharmacological intervention due to the inability to remove self-antigens.

Impact:

• Highlights the antigen-specific nature of immunologic diarrhea.
• Informs therapeutic strategies by distinguishing between antigen-eliminable and non-eliminable conditions.
• Underscores the need for anti-inflammatory and immunosuppressive therapies in autosensitization.