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Updated: Oct 13, 2026

Experimental Human Pneumococcal Carriage
Published on: February 15, 2013
Prophylaxis for Pneumocystis carinii pneumonia in patients infected with human immunodeficiency virus
1Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland 20892.
Abstract:
Following the initial observation by Dr. Margaret Fischl that trimethoprim-sulfamethoxazole can prevent Pneumocystis carinii infection in patients with Kaposi's sarcoma, initiating prophylaxis for pneumocystic infection in all patients with less than 200 CD4+ cells/mm3 has become accepted practice. This prophylactic intervention has been found not only to reduce the development of pneumonia due to P. carinii but also to prolong life. Drs. Henry Masur and Joseph A. Kovacs first reviewed prophylaxis for P. carinii pneumonia in patients infected with the human immunodeficiency virus for the AIDS Commentary 3 years ago. They have updated that initial review for this AIDS Commentary, placing currently available information into concise clinical perspective and detailing a rational plan for the clinician to follow based on results of recent studies.
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