Response of Xenopus laevis to cadmium administration

1. Levels of copper, zinc and cadmium have been determined in the plasma, liver and kidneys of Xenopus laevis. 2. Administration of cadmium by subcutaneous injection induces metallothionein synthesis in the liver of Xenopus laevis. Cadmium is found to accumulate in both liver and kidneys following injection. 3. Cadmium uptake, following injection, is biphasic, suggesting a saturable first-phase uptake mechanism, followed by a linear second phase. 4. Zinc is displaced from the liver by administration of cadmium in a dose-dependent manner.