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cAMP-dependent protein kinase activation mediated by beta 3-adrenergic receptors parallels lipolysis in rat
D Langin1, D Ekholm, M Ridderstråle
1Department of Medical and Physiological Chemistry 4, Lund University, Sweden.
Biochimica Et Biophysica Acta
|June 29, 1992
Abstract:
Catecholamine-induced lipolysis is chiefly mediated through the recently characterized beta 3-adrenergic receptor (AR) in rat adipocytes. Discrepancies between the ability of beta 3-AR agonists to stimulate adenylyl cyclase and the resulting lipolysis were recently reported. cAMP-dependent protein kinase (A-kinase) activation induced by these agonists was compared to lipolysis. Agonist potencies were similar for A-kinase activity ratios and lipolysis. The same A-kinase activity ratio to lipolysis relationship was found for the beta 3-AR agonists tested.