Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitric oxide and neurons.

S H Snyder1

  • 1Department of Neuroscience, Johns Hopkins Medical Institution, Baltimore, Maryland 21205.

Current Opinion in Neurobiology
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

Nitric oxide (NO) acts as a neurotransmitter in the nervous system, influencing synaptic plasticity. Dysregulation of NO may contribute to neurotoxicity in stroke and neurodegenerative diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Projections and chemical coding of neurons with immunoreactivity for nitric oxide synthase in the guinea-pig small intestine.

Neuroscience letters·1992
Same author

Generation of superoxide by purified brain nitric oxide synthase.

The Journal of biological chemistry·1992
Same author

Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide.

Proceedings of the National Academy of Sciences of the United States of America·1992
Same author

Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease.

Annals of neurology·1992
Same author

Molecular messengers of olfaction.

Trends in neurosciences·1992
Same author

Evidence for involvement of nitric oxide in the regulation of hypothalamic portal blood flow.

Neuroscience·1992

Area of Science:

  • Neuroscience
  • Neurochemistry

Background:

  • Emerging evidence suggests nitric oxide (NO) functions as a neurotransmitter in the central and peripheral nervous systems.
  • NO plays a role in synaptic plasticity, including long-term potentiation and long-term depression.

Purpose of the Study:

  • To summarize the recent evidence on the role of nitric oxide in neurotransmission and synaptic plasticity.
  • To explore the potential involvement of abnormal nitric oxide secretion in neurotoxicity and related diseases.

Main Methods:

  • Review of recent scientific literature and evidence.
  • Analysis of studies investigating nitric oxide's function in neuronal signaling and plasticity.

Main Results:

  • Strong evidence supports nitric oxide's role as a neurotransmitter.

Related Experiment Videos

  • Nitric oxide is implicated in mediating synaptic plasticity in brain regions like the hippocampus and cerebellum.
  • Abnormal nitric oxide secretion is linked to NMDA receptor-mediated neurotoxicity.

    • Conclusions:

    • Nitric oxide is a key player in neurotransmission and synaptic plasticity.
    • Aberrant nitric oxide signaling may underlie the pathophysiology of strokes and neurodegenerative conditions.