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Spontaneous conversion of PrPC to PrPSc
1Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263.
FEBS Letters
|July 28, 1992
Abstract:
Octa-repeats of prion proteins (PrP) contain histidine and tryptophan residues which are known to function as ligands for transition metals. It is proposed that the spontaneous conversion of the PrPC (cellular) isoform into PrPSc (scrapie) isoform may be triggered by the coordination of these metals.