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Comparative review of third-generation progestins.
1R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey.
International Journal of Fertility
|January 1, 1992
Summary
Newer progestins like desogestrel, gestodene, and norgestimate in oral contraceptives offer high efficacy with reduced metabolic and androgenic effects compared to older options.
Area of Science:
- Endocrinology and Reproductive Health
Background:
- Oral contraceptives (OCs) utilize progestins to prevent pregnancy.
- Older progestins have been associated with adverse metabolic and androgenic effects.
Purpose of the Study:
- To review the clinical profiles of newer generation progestins: desogestrel, gestodene, and norgestimate.
- To compare these newer progestins with older formulations in combined oral contraceptives.
Main Methods:
- Review of clinical profiles of desogestrel, gestodene, and norgestimate combined with ethinyl estradiol.
- Direct comparisons with older combined oral contraceptives where applicable.
Main Results:
- Newer progestins demonstrate high contraceptive efficacy.
- These progestins exhibit significantly less impact on lipid and carbohydrate metabolism.
- Reduced androgenic activity compared to older progestins was observed.
Conclusions:
- Desogestrel, gestodene, and norgestimate represent advancements in oral contraceptive progestin development.
- These newer progestins offer improved metabolic and androgenic profiles, enhancing the safety and tolerability of combined oral contraceptives.