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Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells
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Protein oxidation and aging

E R Stadtman1

  • 1Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Science (New York, N.Y.)
|August 28, 1992
PubMed
Summary

Oxidative modification of proteins by oxygen free radicals leads to enzyme degradation, increasing with age and disease. This age-related protein damage may stem from unrepaired DNA damage affecting protein oxidation and degradation rates.

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