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Alcohol-preferring rats have fewer dopamine D2 receptors in the limbic system
E Stefanini1, M Frau, M G Garau
1Bernard B. Brodie Department of Neuroscience, University of Cagliari, Italy.
Alcohol and Alcoholism (Oxford, Oxfordshire)
|March 1, 1992
Abstract:
Dopamine D2 receptors in nucleus accumbens, olfactory tubercle and caudate nucleus of Sardinian ethanol-preferring (SP), and non-preferring (SNP) rats were compared by using [3H]YM-09151-2 binding. SP rats exhibited, in each area, lower density of D2 receptors than SNP and unselected Wistar (UW) rats. The results suggest that reduction in D2 receptors in SP rats may be relevant to their innate preference for alcohol.