[The correlation between clozapine saliva level and clinical response as well as side effect in patient with...

It was measured for clozapine saliva level in 62 patients with schizophrenia taking clozapine, the study have found that therapeutic window was at the range from 550 ng/ml to 920 ng/ml in 34 patients with duration more than two years and was at the range from 400 ng/ml to 510 ng/ml in 28 patients with duration less than two years. Clozapine saliva concentration has positively correlated with improvement of though disorders and hostility & suspiciousness in 30 patients with duration more than two years and with improvement of activation in 12 patients with duration less than two years and with anti-adrenergic side effect in 62 patients, the latter effect was significant increased when clozapine saliva level was more than 380 ng/ml.