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Related Experiment Videos

Lichen planus annularis: an immunohistochemical study.

Y Ohta1, K Yonemoto, T Asai

  • 1Department of Dermatology, National Yokohama Hospital, Japan.

The Journal of Dermatology
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

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Annular lichen planus, a rare skin condition, involves specific molecular changes. Intercellular Adhesion Molecule-1 (ICAM-1) and Tumor Necrosis Factor-alpha (TNF-alpha) expression in peripheral cells are key to forming these unique annular lesions.

Area of Science:

  • Dermatology
  • Immunohistochemistry
  • Cutaneous Pathology

Background:

  • Lichen planus annularis is an uncommon presentation of lichen planus.
  • The pathogenesis of its characteristic annular lesions remains unclear.
  • Understanding these mechanisms is crucial for potential therapeutic targets.

Observation:

  • A case study of a 57-year-old female with lichen planus annularis is presented.
  • The eruption evolved from papules to umbilicated plaques before forming annular lesions.
  • Immunohistochemical analysis examined different stages of lesion development.

Findings:

  • HLA-DR expression was observed in keratinocytes adjacent to dermal infiltrates across all lesion types.
  • Intercellular Adhesion Molecule-1 (ICAM-1) expression was noted in keratinocytes above dermal infiltrates.

Related Experiment Videos

  • Notably, peripheral epidermal cells in umbilicated plaques showed extensive ICAM-1 reactivity, and TNF-alpha was positive in upper dermal cells of these plaques.

    • Implications:

    • The study highlights the significant roles of ICAM-1 and TNF-alpha in the development of annular lichen planus lesions.
    • These findings suggest specific molecular pathways involved in the unique morphology of this skin condition.
    • Further research into these molecular events could inform future treatment strategies for lichen planus annularis.