[Insulin sensitivity during use of adrenoblockers and adrenomimetics]

The effect of adrenergic blocking agents and adrenomimetics on sensitivity to insulin was studied in rat experiments. The sensitivity was judged from the duration of hypoglycemic coma development after intravenous infusion of 40 U/kg insulin. Sensitivity to insulin increased with the beta-adrenergic blocking agent obsidan and the alpha-adrenomimetic mesaton (phenylephrine hydrochloride) but diminished after infusion of the beta-adrenomimetic partusisten and the alpha-adrenergic blocking agent butyroxane. The obtained data are discussed from the standpoint of insulin-resistance control.