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Chronic 3,4-methylenedioxymethamphetamine (MDMA) use: effects on mood and neuropsychological function?
J H Krystal1, L H Price, C Opsahl
1Psychiatry Service, Yale University School of Medicine, West Haven VA Medical Center, Connecticut 06516.
The American Journal of Drug and Alcohol Abuse
|January 1, 1992
Summary
Extensive use of 3,4-Methylenedioxymethamphetamine (MDMA) may impair memory and cognitive function, even without apparent mood disorders. This study suggests potential long-term neuropsychological effects of MDMA, warranting further investigation.
Area of Science:
- Neuroscience
- Psychology
Background:
- 3,4-Methylenedioxymethamphetamine (MDMA) is a known serotonin (5-HT) neurotoxin in animal models.
- Preliminary human studies suggest 5-HT deficits linked to extensive MDMA use.
Purpose of the Study:
- To investigate the cognitive and mood effects of chronic MDMA use.
- To assess neuropsychological function in individuals with extensive MDMA use histories.
Main Methods:
- Studied nine individuals with extensive MDMA use.
- Administered the Wechsler Memory Scale (Initial and Delayed Paragraph Tests).
- Conducted a neuropsychological test battery.
Main Results:
- Observed mild-to-moderate impairment on memory tests in most subjects.
- Eight subjects showed impairment on at least one neuropsychological test.
- No subjects reported depressed mood or met clinical criteria for affective disorders.
Conclusions:
- MDMA use may have detrimental effects on neuropsychological function.
- Highlights the need for systematic study of MDMA's long-term cognitive impacts.
- Raises questions about 5-HT deficits' effects on cognition and mood regulation.