Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new perspective on stress ulcer prophylaxis.

R F Sing1, P L Marino

  • 1Department of Surgery, Graduate Hospital, Philadelphia, PA 19146.

The Journal of the American Osteopathic Association
|August 1, 1992
PubMed
Summary

Gastric acid suppression for stress ulcer prophylaxis may increase risks like pneumonia and sepsis due to bacterial overgrowth. Alternative therapies should be considered to avoid routine acid suppression in critically ill patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nationwide outcomes of nontrauma splenectomy.

Surgical endoscopy·2013
Same author

Hand-assisted laparoscopic splenectomy.

Surgical technology international·2010
Same author

A re-evaluation of vagotomy and gastrojejunostomy for benign gastric outlet obstruction.

Journal of laparoendoscopic & advanced surgical techniques. Part A·2006
Same author

Laparoscopic ventral hernia repair: a single center experience.

Hernia : the journal of hernias and abdominal wall surgery·2006
Same author

Thrombosis in the portal venous system after elective laporoscopic splenectomy.

Surgical endoscopy·2005
Same author

Susceptibility of prosthetic biomaterials to infection.

Surgical endoscopy·2005

Area of Science:

  • Critical care medicine
  • Gastroenterology
  • Infectious disease

Background:

  • Gastric acid suppression using antacids or histamine H2-receptor antagonists is standard for stress ulcer prophylaxis.
  • Emerging evidence suggests gastric acid has antimicrobial properties, necessitating a review of acid suppression's role.
  • Elevated gastric pH (>4.0) promotes bacterial overgrowth in the upper gastrointestinal tract.

Purpose of the Study:

  • To reevaluate the routine use of gastric acid suppression in critically ill patients.
  • To highlight the risks associated with elevated gastric pH and bacterial colonization.
  • To advocate for alternative prophylactic strategies.

Main Methods:

  • Review of existing evidence on gastric acid suppression and its consequences.
  • Analysis of the link between gastric pH, bacterial overgrowth, and adverse outcomes.
  • Evaluation of alternative therapeutic options for stress ulcer prophylaxis.

Main Results:

  • Gastric acid suppression can lead to a gastric pH >4.0.
  • This elevated pH is associated with upper gastrointestinal bacterial overgrowth.
  • Bacterial overgrowth is linked to nosocomial pneumonia, bacterial translocation, sepsis, and multiple-organ failure.

Conclusions:

  • Routine gastric acid suppression in critically ill patients warrants reevaluation due to potential harm.
  • The antimicrobial function of gastric acid is significant.
  • Alternative therapies should be prioritized over routine acid suppression to mitigate risks.

Related Experiment Videos