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Taxol: quantitative internuclear proton-proton distances in CDCl3 solution from nOe data: 2D nmr ROESY buildup rates
B D Hilton1, G N Chmurny, G M Muschik
1Program Resources, Inc./DynCorp, NCI-Frederick Cancer Research and Development Center, Maryland 21702.
Journal of Natural Products
|August 1, 1992
Abstract:
Quantitative nmr internuclear proton-proton distance measurements obtained by observation of the initial buildup rates of nOe's in 2D ROESY spectra of taxol [1] in CDCl3 are reported. A comparison to the X-ray crystal structure of taxotere [2] is made, and the results are discussed in terms of previous studies of structure-activity relationships.