Effect of compressional forces on piroxicam polymorphs

Area of Science:

• Pharmaceutical Sciences
• Materials Science

Background:

• Piroxicam exhibits polymorphism, with different crystal forms affecting its physicochemical properties.
• Understanding solid-state transformations is crucial for drug formulation and stability.

Purpose of the Study:

• To investigate the impact of compressional force on piroxicam's polymorphic forms.
• To characterize the transition from needle-shaped to cubic piroxicam polymorphs.

Main Methods:

• Differential scanning calorimetry (DSC) for thermal analysis.
• Powder X-ray diffractometry (PXRD) for crystal structure identification.
• Dissolution rate testing of piroxicam tablets.

Main Results:

• Compression of pure piroxicam polymorphs induced a phase transition.
• The needle-shaped piroxicam polymorph converted to the cubic polymorph under applied pressure.
• Dissolution rates may be altered due to this compression-induced polymorphic change.

Conclusions:

• Compressional force is a critical factor influencing piroxicam's solid-state form.
• The transition to the cubic polymorph during tablet compression needs consideration for formulation development.