[Effect of physiologically active polymers on the activity and hormonal induction of tyrosine aminotransferase]

Effect of neutral polymers on activity of tyrosine aminotransferase and hydrocortisone induction of the enzyme were studied. Physiologically active polymers decreased in most cases the basal rate of the enzymatic activity. Preadministration of polymers decreased hormonal induction of tyrosine aminotransferase. Simultaneous administration of polymers and hydrocortisone led to augmented and long-term induction, which appears to occur due to complex-formation of the polymer and hormone. Gradual liberation of hydrocortisone from the complex enabled to maintain the hormone effective concentration for a long time.