Radical surgery for gallbladder carcinoma. Long-term results

Area of Science:

• Oncology
• Surgical Oncology
• Gastrointestinal Surgery

Background:

• Gallbladder carcinoma presents significant treatment challenges.
• Radical surgery with lymph node dissection is a primary treatment modality.
• Evaluating long-term outcomes is essential for optimizing patient care.

Purpose of the Study:

• To assess the effectiveness of radical surgery and lymph node dissection for gallbladder carcinoma.
• To analyze the long-term survival rates based on lymph node status and resection margins.

Main Methods:

• A retrospective analysis of 40 patients with gallbladder carcinoma.
• Patients were categorized into two groups: those with and without positive lymph nodes.
• Surgical outcomes were evaluated based on R0 (complete), R1 (microscopic residual), and R2 (macroscopic residual) resections.

Main Results:

• In patients without positive nodes, the 5-year survival rate was 85% (17/20) with R0 resection.
• In patients with positive nodes, the 5-year survival rate was 45% (9/20), with R0 resection yielding a 69% (9/13) survival rate.
• R1 or R2 resections in node-positive patients resulted in death within 5 years, highlighting the importance of complete resection.

Conclusions:

• Radical surgery with lymph node dissection demonstrates favorable long-term results for gallbladder carcinoma.
• R0 resection is a critical prerequisite for achieving long-term survival in these patients.
• The findings support the continued use of radical surgery with lymph node dissection for gallbladder cancer.