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Characteristics of the T cell-mediated immune response to maedi-visna virus
H T Reyburn1, D J Roy, B A Blacklaws
1Department of Veterinary Pathology, University of Edinburgh, United Kingdom.
Virology
|December 1, 1992
Abstract:
Virus-specific T cell-mediated immunity was investigated in healthy sheep persistently infected with the ruminant lentivirus maedi-visna. Visna-specific lymphocyte proliferation was demonstrated in response to both purified virions and recombinant p25, the major core protein of maedi-visna virus. The responding T cell population in this assay was mainly of the CD4+ phenotype, although in some individuals CD8+ T cells were also shown to respond to visna antigen in this system.